| ncRNA name | MALAT1 |
| ncRNA Category | lncRNA |
| ID | 378938 |
| Ensembl | ENSG00000251562 |
| Synonyms | HCN, LINC00047, MALAT-1, NCRNA00047, NEAT2, PRO1073, mascRNA |
| Disease name | diabetic cataract |
| Species | Homo sapiens |
| Tissues/Cell_line | anterior lens capsule tissues; human lens epithelial cell line SRA01/04 |
| Methods | qRT-PCR, Western blot, chromatin immunoprecipitation (CHIP), luciferase reporter assay, MTT assay, flow cytometry |
| Expression pattern | up-regulated |
| Functional description | HG induced the up-regulation of MALAT1 in HLECs via SP1 binding SP1 binding MALAT1, which promoted the apoptosis and oxidative stress of HLECs through the activation of p38MAPK signaling pathway. |
| PubMed ID | 29936249 |
| Year | 2018 |
| Title | LncRNA MALAT1 promotes the apoptosis and oxidative stress of human lens epithelial cells via p38MAPK pathway in diabetic cataract. |
| Drug-related ncRNA | NO |
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